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Noxytiolin and peritoneal adhesion formation

Gilmore OJ et al., 1976

The British journal of surgery, 63(12), 978-980

DOI 10.1002/bjs.1800631224 PMID 1034491 Source

Abstract

Clinical and experimental studies have suggested that intraperitoneal noxytiolin prevents adhesion formation. A reliable experimental animal model was therefore established and the effect of noxytiolin on adhesion formation was evaluated in a controlled trial using 80 rats. All 40 rats given Ringer solution developed adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P less than 0-02). Noxytiolin reduced both the total and the mean number of adhesions formed (P less than 0-2) and their mean length of attachment (P less than 0-05). The anti-adhesive effect of noxytiolin may be due to its anticoagulant, cytotoxic or antibacterial properties.

Topics

Surgery > Adhesion Prevention > BarriersSurgery > Laparoscopy > TechniqueInfertility > Female Factor > Tubal Factor
adhesion prevention surgery, noxytiolin peritoneal adhesions, preventing scar tissue after surgery, fertility preserving surgical technique, tubal surgery adhesion barriers, laparoscopy adhesion prevention, intraperitoneal adhesion formation, microsurgery adhesion reduction, surgical technique adhesions, postoperative adhesion prevention, tubal patency surgical outcomes, fertility sparing surgery complications

Cite this article

Gilmore, O. J., & Reid, C. (1976). Noxytiolin and peritoneal adhesion formation. *The British journal of surgery*, *63*(12), 978-980. https://doi.org/10.1002/bjs.1800631224

Keywords

Animals, Disease Models, Animal, Female, Injections, Intraperitoneal, Noxythiolin, Peritoneal Diseases, Peritoneum, Rats, Thiourea, Tissue Adhesions

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