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Natural progesterone and antihypertensive action

K. J. Lafferty, J.C. de Trafford, J. W. W. Studd, Mark Brincat, S Brincat, V Parsons, P B Rylance

  • Renal Research Institute ROR
  • University of Basel ROR
  • University of Milan ROR

British Medical Journal (Clinical Research Ed.), 290(6461), 13-14

DOI 10.1136/bmj.290.6461.13 PMID 3917316

Abstract

In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment and during administration of placebo progesterone caused a significant reduction in blood pressure, suggesting that progesterone has an antihypertensive action rather than a hypertensive one as has been previously thought. This possible protective effect of progesterone should be investigated further.

Topics

Reproductive Endocrinology
natural progesterone antihypertensive, oral progesterone blood pressure, progesterone hypertension treatment, placebo controlled progesterone study, steroid hormone cardiovascular effects, progesterone aldosterone antagonism, natural progesterone oral pharmacology, postmenopausal hypertension progesterone, double blind crossover blood pressure, progesterone mineralocorticoid effect
PMID 3917316 3917316 DOI 10.1136/bmj.290.6461.13 10.1136/bmj.290.6461.13

Cite this article

Rylance, P. B., Brincat, M., Lafferty, K., De Trafford, J. C., Brincat, S., Parsons, V., & Studd, J. W. (1985). Natural progesterone and antihypertensive action. *British medical journal (Clinical research ed.)*, *290*(6461), 13-14. https://doi.org/10.1136/bmj.290.6461.13

Keywords

Adult, Aged, Clinical Trials As Topic, Double-Blind Method, Female, Humans, Hypertension/drug Therapy, Male, Menopause, Middle Aged, Posture, Progesterone/therapeutic Use, Progesterone

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