The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(19), 3234-3237
To evaluate whether myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) rate in overweight women.
In an open-label, randomized trial, myo-inositol (2 g plus 200 μg folic acid twice a day) or placebo (200 μg folic acid twice a day) was administered from the first trimester to delivery in pregnant overweight non-obese women (pre-pregnancy body mass index ≥ 25 and < 30 kg/m(2)). The primary outcome was the incidence of GDM.
From January 2012 to December 2014, 220 pregnant women were randomized at two Italian University hospitals, 110 to myo-inositol and 110 to placebo. The incidence of GDM was significantly lower in the myo-inositol group compared to the placebo group (11.6% versus 27.4%, respectively, p = 0.004). Myo-inositol treatment was associated with a 67% risk reduction of developing GDM (OR 0.33; 95% CI 0.15-0.70).
Myo-inositol supplementation, administered since early pregnancy, reduces GDM incidence in overweight non-obese women.
Santamaria, A., Di Benedetto, A., Petrella, E., Pintaudi, B., Corrado, F., D'Anna, R., Neri, I., & Facchinetti, F. (2016). Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. *The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians*, *29*(19), 3234-3237. https://doi.org/10.3109/14767058.2015.1121478
Santamaria A, Di Benedetto A, Petrella E, Pintaudi B, Corrado F, D'Anna R, et al. Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. J Matern Fetal Neonatal Med. 2016;29(19):3234-3237. doi:10.3109/14767058.2015.1121478
Santamaria, A., et al. "Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial." *The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians*, vol. 29, no. 19, 2016, pp. 3234-3237.
Blood Glucose, Vitamin B Complex, Inositol