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Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial

Santamaria A et al., 2015

Santamaria A, Petrella E, Pintaudi B, Corrado F, D'Anna R, Neri I, Facchinetti F, Di Benedetto A

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(19), 3234-3237, 2016

Source DOI PubMed

Abstract

Objective

To evaluate whether myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) rate in overweight women.

Methods

In an open-label, randomized trial, myo-inositol (2 g plus 200 μg folic acid twice a day) or placebo (200 μg folic acid twice a day) was administered from the first trimester to delivery in pregnant overweight non-obese women (pre-pregnancy body mass index ≥ 25 and < 30 kg/m(2)). The primary outcome was the incidence of GDM.

Results

From January 2012 to December 2014, 220 pregnant women were randomized at two Italian University hospitals, 110 to myo-inositol and 110 to placebo. The incidence of GDM was significantly lower in the myo-inositol group compared to the placebo group (11.6% versus 27.4%, respectively, p = 0.004). Myo-inositol treatment was associated with a 67% risk reduction of developing GDM (OR 0.33; 95% CI 0.15-0.70).

Conclusions

Myo-inositol supplementation, administered since early pregnancy, reduces GDM incidence in overweight non-obese women.

Topics

Pregnancy > Outcomes > ComplicationsPCOS > Metabolic Effects > Diabetes RiskGeneral OB/GYN > Clinical Practice > Standards
myo inositol gestational diabetes prevention, inositol supplementation gdm overweight women, myo inositol pregnancy glucose metabolism, preventing gestational diabetes inositol, inositol first trimester gdm risk reduction, overweight pregnancy nutritional intervention, myo inositol randomized trial pregnancy, gestational diabetes prevention supplements, inositol folic acid pregnancy outcomes, gdm prevention overweight non obese women

Cite this article

Santamaria, A., Petrella, E., Pintaudi, B., Corrado, F., D'Anna, R., Neri, I., Facchinetti, F., & Di Benedetto, A. (2015). Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. *The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians*, *29*(19), 3234-3237. https://doi.org/10.3109/14767058.2015.1121478

Keywords

Adult, Blood Glucose, Body Mass Index, Diabetes, Gestational, Dietary Supplements, Female, Humans, Incidence, Inositol, Overweight, Pregnancy, Vitamin B Complex, Gestational Diabetes, Myo-inositol, Obese

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