0

Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy

Karjalainen A et al., 1997

British journal of obstetrics and gynaecology, 104 Suppl 16(s16), 38-43

DOI 10.1111/j.1471-0528.1997.tb11566.x PMID 9389782 Source

Abstract

Objective

To investigate changes in plasma lipid and lipoprotein levels induced by peroral oestrogen replacement and transdermal oestradiol gel therapy.

Design

The effects of peroral oestradiol valerate tablets (2 mg) and placebo gel were compared with 1g transdermal oestradiol gel (1mg oestradiol) and placebo tablets in a randomised, double-blind, double-dummy study for 6 months.

Setting

Department of Internal Medicine, University of Oulu and Oulu Deaconess Institute, Oulu, Finland. POPULATION: Seventy-nine hysterectomised, postmenopausal women, 39 women in the peroral oestrogen group and 40 in the gel group.

Main outcome measures

Cholesterol and triglycerides in total plasma and in various lipoprotein fractions, and sex hormones.

Results

In the peroral oestrogen group total and LDL cholesterol were decreased and HDL cholesterol and triglycerides were increased. In the oestradiol gel group plasma total, LDL and VLDL cholesterol and the ratio of LDL/HDL cholesterol were significantly decreased, but no change in HDL cholesterol and triglycerides was observed. Overall the decrease in LDL levels was correlated with the increase in oestrogen levels.

Conclusions

Both peroral and transdermal replacement therapy had beneficial effects on plasma lipids by lowering total and LDL cholesterol and LDL/HDL cholesterol ratio. These changes seem to be associated with changes in oestrogen levels.

Topics

Perimenopause/Menopause > HRT > BenefitsGeneral OB/GYN > Clinical Practice > Standards
oral vs transdermal estrogen lipids, estradiol gel metabolic effects, hormone replacement cholesterol, estradiol valerate lipid profile, transdermal estrogen triglycerides, postmenopausal estrogen ldl cholesterol, estrogen route lipid metabolism, estradiol gel hdl cholesterol, hrt lipid effects comparison, oral estrogen hepatic first pass

Cite this article

Karjalainen, A., Heikkinen, J., Savolainen, M. J., Bäckström, A. C., Salinto, M., & Kesäniemi, Y. A. (1997). Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy. *British journal of obstetrics and gynaecology*, *104 Suppl 16*(s16), 38-43. https://doi.org/10.1111/j.1471-0528.1997.tb11566.x

Keywords

Aged, Body Mass Index, Cholesterol, HDL, LDL, Double-Blind Method, Estradiol, Estrogen Replacement Therapy, Estrogens, Female, Follicle Stimulating Hormone, Gels, Humans, Hysterectomy, Luteinizing Hormone, Tablets, Treatment Refusal

Related articles