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Mefenamic acid in the treatment of premenstrual syndrome

S Abraham, D McNeil, M Mira, Ian S Fraser, J Vizzard

  • Royal Hospital for Women ROR

Obstetrics and Gynecology, 68(3), 395-398

DOI 10.1097/00006250-198609000-00022 PMID 3526218

Abstract

The use of mefenamic acid in the treatment of premenstrual syndrome (PMS) was investigated in 15 women over six menstrual cycles. A randomized, double-blind, cross-over, placebo-controlled design was used to overcome the methodologic criticisms of other medication trials in this condition. Mefenamic acid significantly improved many of the physical, mood, and performance symptoms associated with PMS. The physical symptoms that showed marked improvement were fatigue, headache, and general aches and pains (P less than .001). Most mood symptoms were improved, the most significant being freedom from mood swings (P less than .005).

Topics

Menstrual Cycle > Premenstrual Syndrome > Pharmacological TreatmentResearch Methodology > Clinical Trials > Randomized Crossover DesignGeneral OB/GYN > Menstrual Disorders > PMS Management
mefenamic acid premenstrual syndrome treatment, PMS pharmacological treatment randomized controlled trial, mefenamic acid mood symptoms premenstrual syndrome, NSAID treatment premenstrual physical symptoms fatigue headache, double blind crossover placebo controlled PMS medication trial, prostaglandin inhibitor premenstrual syndrome management, mefenamic acid PMS mood swings physical symptoms, Fraser IS premenstrual syndrome mefenamic acid, anti-inflammatory treatment menstrual cycle mood performance, premenstrual syndrome drug therapy evidence based
PMID 3526218 3526218 DOI 10.1097/00006250-198609000-00022 10.1097/00006250-198609000-00022

Cite this article

Mira, M., McNeil, D., Fraser, I. S., Vizzard, J., & Abraham, S. (1986). Mefenamic acid in the treatment of premenstrual syndrome. *Obstetrics and gynecology*, *68*(3), 395-398. https://doi.org/10.1097/00006250-198609000-00022

Keywords

Adult, Clinical Trials As Topic, Double-Blind Method, Female, Humans, Mefenamic Acid/adverse Effects/therapeutic Use, Menstrual Cycle, Premenstrual Syndrome/drug Therapy, Prospective Studies, Mefenamic Acid

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