Mechanism of action of levonorgestrel emergency contraception

  • Florida State University ROR
  • The Polycarp Research Institute, Enola, PA, USA ROR
  • Penn State Milton S. Hershey Medical Center ROR

The Linacre Quarterly, 82(1), 18-33

DOI 10.1179/2050854914Y.0000000026 PMID 25698840

Abstract

There has been much debate regarding levonorgestrel emergency contraception's (LNG-EC's) method of action since 1999 when the Food and Drug Administration first approved its use. Proponents of LNG-EC have argued that they have moral certitude that LNG-EC works via a non-abortifacient mechanism of action, and claim that all the major scientific and medical data consistently support this hypothesis. However, newer medical data serve to undermine the consistency of the non-abortifacient hypothesis and instead support the hypothesis that preovulatory administration of LNG-EC has significant potential to work via abortion. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room protocols. In the future, technology such as the use of early pregnancy factor may have the potential to quantify how frequently preovulatory LNG-EC works via abortion. Lay

Summary

How Plan B (levonorgestrel emergency contraception) works has been vigorously debated ever since the Food and Drug Administration approved it in 1999. Many doctors and researchers claim that it has either no-or at most-an extremely small chance of working via abortion. However, the latest scientific and medical evidence now demonstrates that levonorgestrel emergency contraception theoretically works via abortion quite often. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room rape protocols.

Topics

levonorgestrel emergency contraception mechanism, Plan B mechanism of action, post-fertilization contraceptive effects, emergency contraception ovulation inhibition, levonorgestrel endometrial receptivity, abortifacient vs contraceptive debate, emergency contraception ethical considerations, LNG-EC pharmacology, hormonal emergency contraception luteal phase, Catholic health care emergency contraception
PMID 25698840 25698840 DOI 10.1179/2050854914Y.0000000026 10.1179/2050854914Y.0000000026

Cite this article

Kahlenborn, C., Peck, R., & Severs, W. B. (2015). Mechanism of action of levonorgestrel emergency contraception. *The Linacre Quarterly*, *82*(1), 18-33. https://doi.org/10.1179/2050854914Y.0000000026

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