Maternal progestins as a possible cause of hypospadias

HYPOSPADIAS is a common anomaly of the urogenital system. The prevalence rate reported by various birth-defect monitoring programs shows a rather wide variation, ranging from about five per 10,000 to about 30 per 10,000 births. During recent years increasing incidence has been reported from England and Wales1 and Norway.2 In the United States the Center for Disease Control, Atlanta, Georgia, has noted an annual increase in the reported incidence of 3 per cent per year from 1970 to 1975. Though relatively small, this increase was nevertheless statistically highly significant (P<0.0001).3 More frequent recognition and reporting of the condition may explain . . .