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Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies

Joris van der Post, Peter H Bisschop, Eric Fliers, Mariette Goddijn, Joris A M van der Post, Madelon van Wely, Rosa Vissenberg

  • Academic Medical Center ROR
  • University Hospital and Clinics ROR
  • Academic Medical Centre, Department of Obstetrics and Gynaecology, Amsterdam, The Netherlands.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 32(2), 132-135

DOI 10.3109/09513590.2015.1092513 PMID 26430806

Abstract

Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine.

Topics

Infertility > Recurrent Pregnancy Loss > Thyroid AutoimmunityReproductive Endocrinology > Thyroid Disorders > TPO AntibodiesDiagnostics > Hormonal Testing > Thyroid Antibody Screening
thyroid peroxidase antibodies recurrent miscarriage live birth rate, euthyroid TPO antibody positive recurrent pregnancy loss, levothyroxine treatment recurrent miscarriage thyroid autoimmunity, thyroid autoimmunity unexplained recurrent miscarriage, TPO antibody prevalence women recurrent pregnancy loss, levothyroxine euthyroid recurrent miscarriage outcome, retrospective cohort thyroid antibodies live birth rate, subclinical thyroid autoimmunity reproductive failure, Vissenberg thyroid antibodies miscarriage levothyroxine, thyroid screening recurrent pregnancy loss management
PMID 26430806 26430806 DOI 10.3109/09513590.2015.1092513 10.3109/09513590.2015.1092513

Cite this article

Vissenberg, R., Fliers, E., van der Post, J. A. M., van Wely, M., Bisschop, P. H., & Goddijn, M. (2016). Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies. *Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology*, *32*(2), 132-135. https://doi.org/10.3109/09513590.2015.1092513

Keywords

Abortion, Habitual/blood, Adult, Autoantibodies/blood, Autoantigens/immunology, Female, Humans, Iodide Peroxidase/immunology, Iron-Binding Proteins/immunology, Live Birth, Pregnancy, Retrospective Studies, Thyroxine/therapeutic Use, Autoantibodies, Autoantigens, Iron-Binding Proteins, TPO Protein, Human, Iodide Peroxidase, Thyroxine, Levothyroxine, Live-birth Rate, Pregnancy Rate, Recurrent Miscarriage, Thyroid Autoimmunity, Thyroid Peroxidase Antibodies

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