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Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies

Vissenberg R et al., 2015

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 32(2), 132-135

DOI 10.3109/09513590.2015.1092513 PMID 26430806 Source

Abstract

Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine.

Topics

Pregnancy > Recurrent Loss > TreatmentReproductive Endocrinology > Thyroid > AutoimmuneReproductive Endocrinology > Thyroid > Fertility ImpactPregnancy > Outcomes > Miscarriage Rates
thyroid antibodies recurrent miscarriage, tpo antibodies and pregnancy loss, levothyroxine treatment recurrent miscarriage, thyroid peroxidase antibodies live birth rate, euthyroid women with thyroid antibodies pregnancy, treating thyroid autoimmunity to prevent miscarriage, unexplained recurrent pregnancy loss thyroid, levothyroxine prophylaxis recurrent loss, autoimmune thyroid and live birth outcomes, thyroid antibody positive fertility treatment, tpo positive pregnancy success rates

Cite this article

Vissenberg, R., Fliers, E., van der Post, J. A., van Wely, M., Bisschop, P. H., & Goddijn, M. (2015). Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies. *Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology*, *32*(2), 132-135. https://doi.org/10.3109/09513590.2015.1092513

Keywords

Abortion, Habitual, Adult, Autoantibodies, Autoantigens, Female, Humans, Iodide Peroxidase, Iron-Binding Proteins, Live Birth, Pregnancy, Retrospective Studies, Thyroxine, TPO Protein, Human, Levothyroxine, Live-birth Rate, Pregnancy Rate, Recurrent Miscarriage, Thyroid Autoimmunity, Thyroid Peroxidase Antibodies

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