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Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes

Stiemer B et al., 1997

British journal of obstetrics and gynaecology, 104(4), 499-502

DOI 10.1111/j.1471-0528.1997.tb11504.x PMID 9141589 Source

Abstract

Interleukin-8 (IL-8), a 72 amino acid peptide secreted by cells of the immune system and of the amnion, chorion and decidua, was measured in women in late pregnancy. IL-8 was detected in the urine of 91 of 104 women with premature rupture of the fetal membranes, with values exceeding 1000 ng/L in cases of severe intra-amniotic infection. Women with urinary tract infections were excluded. The routine measurement of IL-8 in urine, together with C-reactive protein in serum, thus provides a low risk and technically simple approach to the assessment of intra-amniotic infection.

Topics

Pregnancy > Outcomes > ComplicationsDiagnostics > Biomarker Monitoring > Urinary Metabolites
interleukin-8 urine intra-amniotic infection, il-8 biomarker premature rupture membranes, prom infection diagnostic marker, urinary interleukin-8 chorioamnionitis, premature rupture membranes infection diagnosis, il-8 c-reactive protein amniotic infection, non-invasive intra-amniotic infection test

Cite this article

Stiemer, B., Buschmann, A., Bisson, S., Hensel, K., Gramm, H. J., Hopp, H., & Weitzel, H. K. (1997). Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes. *British journal of obstetrics and gynaecology*, *104*(4), 499-502. https://doi.org/10.1111/j.1471-0528.1997.tb11504.x

Keywords

Amnion, Enzyme-Linked Immunosorbent Assay, Female, Fetal Membranes, Premature Rupture, Humans, Interleukin-8, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Trimester, Second, Third, Prenatal Diagnosis, Sensitivity and Specificity

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