Human Reproduction (Oxford, England), 3(4), 473-477
Pulsatile administration of gonadotrophin releasing hormone (GnRH) is a very effective treatment for induction of ovulation in hypothalamic amenorrhoea (HA). Thirty-seven women have been treated for a total of 117 cycles which resulted in 42 pregnancies--four treatment failures occurred. If these cycles are excluded, the 42 pregnancies were obtained within 2.3 cycles. One twin pregnancy occurred and no hyperstimulation was observed. The treatment was administered intravenously with a dosage schedule based on the grading of HA. We concluded that pulsatile GnRH was safe and very successful in induction of pregnancy in HA. Other indications (polycystic ovary syndrome and luteal phase defect) remain much less suitable for this treatment.
Gompel, A., & Mauvais-Jarvis, P. (1988). Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea. *Human reproduction (Oxford, England)*, *3*(4), 473-477. https://doi.org/10.1093/oxfordjournals.humrep.a136731
Gompel A, Mauvais-Jarvis P. Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea. Hum Reprod. 1988;3(4):473-477. doi:10.1093/oxfordjournals.humrep.a136731
Gompel, Anne, and P. Mauvais-Jarvis. "Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea." *Human reproduction (Oxford, England)*, vol. 3, no. 4, 1988, pp. 473-477.
Amenorrhea/drug Therapy/etiology, Female, Follicle Stimulating Hormone/blood, Gonadotropin-Releasing Hormone/administration & Dosage/therapeutic Use, Humans, Hypothalamic Diseases/complications, Luteinizing Hormone/blood, Ovulation Induction, Pregnancy, Gonadotropin-Releasing Hormone, Luteinizing Hormone, Follicle Stimulating Hormone