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Identification of two related pentapeptides from the brain with potent opiate agonist activity

Hughes J et al., 1975

Nature, 258(5536), 577-580

DOI 10.1038/258577a0 PMID 1207728 Source

Abstract

Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.

Topics

General OB/GYN > Other > Miscellaneous
enkephalin pentapeptides brain, opiate receptor natural ligands, endogenous opioid peptides, tyr gly gly phe met, opiate agonist peptides, enkephalin amino acid sequence, natural opioid ligands brain, opiate receptor binding peptides

Cite this article

Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975). Identification of two related pentapeptides from the brain with potent opiate agonist activity. *Nature*, *258*(5536), 577-580. https://doi.org/10.1038/258577a0

Keywords

Amino Acid Sequence, Animals, Brain, Brain Chemistry, Ligands, Muscle Contraction, Naloxone, Nerve Tissue Proteins, Oligopeptides, Opium, Receptors, Drug, Swine

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