Hypotensive action of progesterone in experimental and human hypertension

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 102(2), 452-455

DOI 10.3181/00379727-102-25282 PMID 13794314 Source

Summary(1) Progesterone administration to rats and dogs with experimental hypertension and to humans with primary arterial hypertension resulted in a decline in blood pressure levels. Blood pressures increased once more in all cases after progesterone was discontinued. (2) In humans, but not necessarily in rats and dogs, blood pressure reduction would appear to have resulted from natruresis.

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Armstrong, J. G. (1959). Hypotensive action of progesterone in experimental and human hypertension. *Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)*, *102*(2), 452-455. https://doi.org/10.3181/00379727-102-25282