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Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study

Chang CP et al., 2020

Chang CP, Chen Y, Blackburn B, Abdelaziz S, Rowe K, Snyder J, Dodson M, Deshmukh V, Newman M, Stanford JB, Porucznik CA, Ose J, Fraser A, Smith K, Doherty J, Gaffney D, Hashibe M

Gynecologic oncology, 157(2), 529-535, 2020

Source DOI PubMed

Abstract

Objective

While genitourinary complications during treatment for ovarian cancer are well-known, long-term adverse outcomes have not been well characterized. The number of ovarian cancer survivors has been increasing. The aim of this study was to investigate long-term adverse genitourinary outcomes in a population-based cohort.

Methods

We identified a cohort of 1270 ovarian cancer survivors diagnosed between 1996 and 2012 from the Utah Cancer Registry, and 5286 cancer-free women were matched on birth year and state from the Utah Population Database. Genitourinary disease diagnoses were identified through ICD-9 codes from electronic medical records and statewide healthcare facilities data. Cox proportional hazards models were used to estimate hazard ratios (HR) for genitourinary outcomes at 1 to <5 years and 5+ years after ovarian cancer diagnosis.

Results

Ovarian cancer survivors had increased risks for urinary system disorders (HR: 2.53, 95% CI: 2.12-3.01) and genital organ disorders (HR: 1.88, 95% CI: 1.57-2.27) between 1 and <5 years after cancer diagnosis compared to the general population cohort. Increased risks were observed for acute renal failure, chronic kidney disease, calculus of kidney, hydronephrosis, pelvic peritoneal adhesions, and pelvic organ inflammatory conditions. Increased risks of several of these diseases were observed 5+ years after cancer diagnosis.

Conclusions

Ovarian cancer survivors experience increased risks of various genitourinary diseases compared to women in the general population in the long-term. Understanding the multimorbidity trajectory among ovarian cancer survivors is important to improve clinical care after cancer treatment is completed.

Topics

General OB/GYN > Clinical Practice > Long-Term OutcomesSurgery > Adhesion Prevention > OutcomesGeneral OB/GYN > Epidemiology > Prevalence
ovarian cancer survivor genitourinary complications, long term effects ovarian cancer treatment, kidney disease ovarian cancer survivors, pelvic adhesions after ovarian cancer, genitourinary morbidity cancer survivorship, renal failure ovarian cancer treatment, hydronephrosis ovarian cancer survivors, chronic kidney disease gynecologic cancer, pelvic peritoneal adhesions cancer treatment, cancer survivorship genitourinary disorders, ovarian cancer late effects, urinary complications gynecologic oncology

Cite this article

Chang, C. P., Chen, Y., Blackburn, B., Abdelaziz, S., Rowe, K., Snyder, J., Dodson, M., Deshmukh, V., Newman, M., Stanford, J. B., Porucznik, C. A., Ose, J., Fraser, A., Smith, K., Doherty, J., Gaffney, D., & Hashibe, M. (2020). Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study. *Gynecologic oncology*, *157*(2), 529-535. https://doi.org/10.1016/j.ygyno.2020.02.028

Keywords

Adolescent, Adult, Aged, 80 and Over, Cancer Survivors, Cohort Studies, Female, Genital Diseases, Humans, Middle Aged, Neoplasm Staging, Ovarian Neoplasms, Registries, Utah, Young Adult, Cancer Survivorship, Genital Organ Disorders, Genitourinary Diseases, Ovarian Cancer, Urinary System Disorders

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