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Estrogen carcinogenesis in breast cancer

Yager JD et al., 2006

The New England journal of medicine, 354(3), 270-282

DOI 10.1056/NEJMra050776 PMID 16421368 Source

Abstract

Estrogen exposure is a major determinant of the risk of breast cancer. This article reviews how genotoxic, mutagenic metabolites of estrogen and stimulation of tissue growth by the hormone participate in the pathogenesis of breast cancer.

Topics

General OB/GYN > Other > OncologyContraception/Comparison > Side Effects > Hormonal ContraceptionPerimenopause/Menopause > HRT > Risks
estrogen breast cancer mechanism, hormonal carcinogenesis breast tissue, estrogen metabolites dna damage, genotoxic effects estrogen, hormone replacement therapy cancer risk, estrogen receptor breast cancer pathogenesis, synthetic estrogen carcinogenic effects, hormonal contraception breast cancer, estrogen-induced mutations breast

Cite this article

Yager, J. D., & Davidson, N. E. (2006). Estrogen carcinogenesis in breast cancer. *The New England journal of medicine*, *354*(3), 270-282. https://doi.org/10.1056/NEJMra050776

Keywords

Breast Neoplasms, Carcinogens, DNA Damage, Estrogens, Female, Humans, Receptors, Estrogen, Risk Factors, Signal Transduction

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