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Error in histologic dating of secretory endometrium: variance component analysis

Gibson M et al., 1991

Fertility and sterility, 56(2), 242-247

DOI 10.1016/s0015-0282(16)54479-3 PMID 2070853 Source

Abstract

Objective

To characterize the extent and sources of imprecision in histologic dating of the endometrial biopsy.

Design

Duplicate endometrial biopsies from 25 women were dated by five evaluators on two separate occasions to evaluate the overall precision of the measure. Using variance component analysis, estimates of intrauterine, intraevaluator, and interevaluator variability were determined.

Setting

Samples were obtained during outpatient fertility testing. Evaluators were colleagues at the same institution. PATIENTS,

Participants

Women presenting with infertility undergoing routine evaluation.

Interventions

None.

Main outcome measure

Variability in histologic dating of the endometrium.

Results

Inconsistencies between evaluators accounted for 65% of the observed variability, whereas 27% was because of inconsistencies in duplicate readings by the same evaluator. Regional differences in the uterus accounted for only 8% of the total variability.

Conclusions

The overall error from these sources have the potential to result in a substantial false-positive rate for diagnosis of luteal phase defect.

Topics

Reproductive Endocrinology > Luteal Phase > DeficiencyDiagnostics > Hormone Assays > ProgesteroneMenstrual Cycle > Physiology > Luteal Phase
endometrial biopsy dating accuracy, luteal phase defect diagnosis variability, histologic dating endometrium error, observer variability endometrial dating, false positive luteal phase defect, endometrial biopsy interpretation reliability, progesterone deficiency diagnostic precision, variance component endometrial dating, secretory endometrium dating error, luteal phase assessment reliability

Cite this article

Gibson, M., Badger, G. J., Byrn, F., Lee, K. R., Korson, R., & Trainer, T. D. (1991). Error in histologic dating of secretory endometrium: variance component analysis. *Fertility and sterility*, *56*(2), 242-247. https://doi.org/10.1016/s0015-0282(16)54479-3

Keywords

Analysis of Variance, Biopsy, Endometrium, False Positive Reactions, Female, Humans, Luteal Phase, Observer Variation

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