Fertility and Sterility, 33(2), 121-124
One hundred and forty-nine patients presenting with infertility underwent two hundred and ten endometrial biopsies as part of a routine infertility evaluation. The initial biopsy was out of phase in 44 (29.5%), confirmed by subsequent biopsy to yield a total of 28 (19%) patients with luteal phase inadequacy. Of 44 patients taking clomiphene citrate, 13 (29.5%) had out-of-phase biopsies. Although hyperprolactinemia, recurrent miscarriages, extremes of reproductive life, and clomiphene citrate administration have been associated with an increased incidence of the defect, in this series a predisposing cause could not be detected in approximately one-half of the patients. The routinely obtained endometrial biopsy provides a safe, reproducible, and adequate means of providing histologic evidence for normal endometrial development for subsequent implantation.
Wentz, A. C. (1980). Endometrial biopsy in the evaluation of infertility. *Fertility and sterility*, *33*(2), 121-124. https://doi.org/10.1016/s0015-0282(16)44530-9
Wentz AC. Endometrial biopsy in the evaluation of infertility. Fertil Steril. 1980;33(2):121-124. doi:10.1016/s0015-0282(16)44530-9
Wentz, A. C. "Endometrial biopsy in the evaluation of infertility." *Fertility and sterility*, vol. 33, no. 2, 1980, pp. 121-124.
Biopsy, Clomiphene/pharmacology, Endometrium/pathology, Female, Humans, Infertility, Female/diagnosis, Luteal Phase/drug Effects, Menstruation Disturbances/diagnosis, Time Factors, Clomiphene