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Endogenous sex hormones, prolactin, and breast cancer in premenopausal women

Meyer F et al., 1986

Journal of the National Cancer Institute, 77(3), 613-616

DOI 10.1093/jnci/77.3.613 PMID 3462404 Source

Abstract

Forty-one women with breast cancer and 119 controls participated in a case-control study of the relation of endogenous sex hormones to breast carcinoma in premenopausal women. During the follicular phase of the menstrual cycle, one overnight urine specimen was collected. During the luteal phase, urine and blood specimens were obtained. 17 beta-Estradiol, sex hormone-binding globulin, progesterone, and prolactin were measured in plasma, whereas estrogen metabolites (estrone, estradiol, and estriol) and pregnanediol were assessed in the urine. Breast cancer was associated with high-plasma estradiol and prolactin and with low progesterone. Similar but weaker associations were observed for urinary estrogens and pregnanediol in the luteal phase.

Topics

Menstrual Cycle > Biomarkers > HormonalReproductive Endocrinology > Progesterone > PhysiologyReproductive Endocrinology > Estrogen > Clinical Effects
premenopausal breast cancer hormones, estradiol progesterone breast cancer risk, luteal phase hormones malignancy, prolactin breast cancer premenopausal, low progesterone breast cancer association, endogenous estrogen cancer risk, menstrual cycle biomarkers cancer, pregnanediol estrogen metabolites breast, sex hormone binding globulin cancer

Cite this article

Meyer, F., Brown, J. B., Morrison, A. S., & MacMahon, B. (1986). Endogenous sex hormones, prolactin, and breast cancer in premenopausal women. *Journal of the National Cancer Institute*, *77*(3), 613-616. https://doi.org/10.1093/jnci/77.3.613

Keywords

Adult, Breast Neoplasms, Female, Gonadal Steroid Hormones, Humans, Luteal Phase, Menopause, Middle Aged, Prolactin, Risk, Sex Hormone-Binding Globulin

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