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Effects of Ringer's lactate, Interceed(TC7) and Gore-Tex Surgical Membrane on postsurgical adhesion formation

Pagidas K et al., 1992

Fertility and sterility, 57(1), 199-201

DOI 10.1016/s0015-0282(16)54801-8 PMID 1730317 Source

Abstract

Objective

To evaluate the effects of Ringer's lactate instillation, Interceed(TC7) (Johnson and Johnson Medical, Inc., New Brunswick NJ), and Gore-Tex Surgical Membrane (W. L. Gore and Associates, Inc., Flagstaff, AZ) in a rat uterine horn model.

Setting

Rats were in a conventional laboratory setting.

Participants

Sprague-Dawley white rats, weighing 225 to 250 g.

Interventions

The left uterine horn was subjected to a standardized lesion by serosal denudation and devascularization. The rats were randomly assigned into control group, Interceed(TC7) group, Gore-Tex group, and Ringer's lactate group.

Main outcome measures

Degree of adhesions was evaluated 2 weeks after the initial surgery.

Results

Adhesion score after Ringer's lactate instillation was significantly lower than those of control, Interceed(TC7), and Gore-Tex groups. Gore-Tex was associated with less adhesion formation than control. No difference was found in the adhesion formation between the Interceed(TC7) group and the control group.

Conclusion

Confirming our previous observations, Ringer's lactate instillation is effective in decreasing adhesion formation. Gore-Tex reduces adhesion formation, but its efficacy is inferior to those of Ringer's lactate. Contrary to previous reports, Interceed(TC7) is ineffective in our animal model.

Topics

Surgery > Adhesion Prevention > BarriersSurgery > Laparoscopy > Technique
adhesion prevention pelvic surgery, interceed adhesion barrier, gore-tex surgical membrane adhesions, ringers lactate instillation surgery, postoperative adhesion formation, fertility sparing surgery adhesions, adhesion barrier comparison study, uterine surgery adhesion prevention, laparoscopy adhesion barriers, oxidized cellulose adhesion prevention

Cite this article

Pagidas, K., & Tulandi, T. (1992). Effects of Ringer's lactate, Interceed(TC7) and Gore-Tex Surgical Membrane on postsurgical adhesion formation. *Fertility and sterility*, *57*(1), 199-201. https://doi.org/10.1016/s0015-0282(16)54801-8

Keywords

Animals, Cellulose, Oxidized, Female, Isotonic Solutions, Membranes, Artificial, Polytetrafluoroethylene, Postoperative Complications, Rats, Inbred Strains, Ringer's Lactate, Tissue Adhesions, Uterine Diseases, Uterus, INTERCEED

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