Effect of the suppository base on progesterone delivery from the vagina

Price JH, Ismail H, Gorwill RH, Sarda IR

doi:10.1016/s0015-0282(16)46938-4

Effect of the suppository base on progesterone delivery from the vagina

H Ismail, J D Price, R H Gorwill, I R Sarda

Queen's University ROR
Vancouver Clinic ROR

Fertility and Sterility, 39(4), 490-493

DOI 10.1016/s0015-0282(16)46938-4 PMID 6832405

Abstract

Inadequate levels of circulating progesterone (P) seen in clinical practice can be increased by P supplementation. When supplementation is via the vaginal route, its presentation may be in many different suppository bases. We have measured circulating P in the follicular phase to compare delivery from the vagina after P was presented in three different bases (glycerinated gelatin, cocoa butter, and polyethylene glycol). The mean peak level achieved and the area under the curve were highest after supplementation from polyethylene glycol-based suppositories. The duration of elevation above baseline was similar with all three suppositories. It is concluded that the suppository base is important in controlling the amount of this steroid absorbed from a given amount presented by this route.

Topics

Reproductive Endocrinology > Progesterone Therapy > Vaginal Administration Reproductive Endocrinology > Pharmacology > Drug Delivery Systems Infertility > Treatment > Progesterone Supplementation

vaginal progesterone suppository base absorption, progesterone delivery vaginal route suppository formulation, polyethylene glycol cocoa butter progesterone suppository, progesterone supplementation vaginal bioavailability, suppository base progesterone serum levels comparison, glycerinated gelatin progesterone vaginal absorption, Price Gorwill progesterone vaginal suppository, luteal phase progesterone supplementation route, progesterone pharmacokinetics vaginal administration, follicular phase progesterone suppository absorption study

PMID 6832405 6832405 DOI 10.1016/s0015-0282(16)46938-4 10.1016/s0015-0282(16)46938-4

Cite this article

Price, J. H., Ismail, H., Gorwill, R. H., & Sarda, I. R. (1983). Effect of the suppository base on progesterone delivery from the vagina. *Fertility and sterility*, *39*(4), 490-493. https://doi.org/10.1016/s0015-0282(16)46938-4

Keywords

Adolescent, Adult, Female, Gelatin Sponge, Absorbable, Glycerol, Humans, Luteal Phase, Polyethylene Glycols, Progesterone/administration & Dosage/metabolism, Suppositories, Vagina, Suppositories, Polyethylene Glycols, Progesterone, Glycerol

Effect of the suppository base on progesterone delivery from the vagina

Abstract

Topics

Cite this article

Keywords

Related articles

The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone

The efficacy of progesterone in achieving successful pregnancy: I. Prophylactic use during luteal phase in anovulatory women

Neonatal characteristics of children conceived with in vitro fertilization or intrauterine insemination compared with sibling births from unassisted conceptions

Disordered eating behaviors during adolescence and risk of endometriosis: a prospective cohort study