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Effect of estriol on bone loss in postmenopausal Japanese women: a multicenter prospective open study

Minaguchi H et al., 1996

The journal of obstetrics and gynaecology research, 22(3), 259-265

DOI 10.1111/j.1447-0756.1996.tb00976.x PMID 8840712 Source

Abstract

Objectives

To assess the effects of oral estriol on the bone mineral density (BMD) and bone metabolism in postmenopausal women.

Methods

Seventy-five natural postmenopausal women with a BMD of more than 10% below the peak bone density were treated for 50 weeks with 2 mg/day estriol (E3) cyclically and 0.8 g/day of calcium lactate continuously. BMDs at L2-L4 were measured by dual energy X-ray absorptiometry (DXA).

Results

The BMD increased 1.79% (p < 0.01 vs. pretreatment) after 50 weeks, accompanied with decrease of biochemical markers of bone turnover. With regard to climacteric symptoms, Kupperman's menopausal index improved (p < 0.01 vs. pretreatment) after 5 weeks of treatment. As to the incidence of adverse events genital bleeding was observed in only 8.0% of the subjects. Endometrial histology and cytology showed neither abnormalities nor hyperplasia during and after the treatment.

Conclusions

Estriol prevented postmenopausal bone loss and improved climacteric symptoms effectively with low incidence of genital bleeding.

Topics

Perimenopause/Menopause > HRT > BenefitsBone Health > Osteoporosis Risk > PremenopausalPerimenopause/Menopause > Bone Health > Density
estriol bone density postmenopausal, estriol osteoporosis prevention, estriol menopause bone loss, weak estrogen bone health, estriol climacteric symptoms, estriol dual energy x-ray absorptiometry, postmenopausal bone mineral density treatment, estriol versus estradiol bone, estriol kupperman index

Cite this article

Minaguchi, H., Uemura, T., Shirasu, K., Sato, A., Tsukikawa, S., Ibuki, Y., Mizunuma, H., Aso, T., Koyama, T., Nozawa, S., Ohta, H., Ikeda, T., Kusuhara, K., Ochiai, K., Kato, J., Kinoshita, T., Tanaka, K., Minagawa, Y., Kurabayashi, T., & Fukunaga, M. (1996). Effect of estriol on bone loss in postmenopausal Japanese women: a multicenter prospective open study. *The journal of obstetrics and gynaecology research*, *22*(3), 259-265. https://doi.org/10.1111/j.1447-0756.1996.tb00976.x

Keywords

Bone Density, Climacteric, Estriol, Female, Humans, Middle Aged, Osteoporosis, Postmenopausal, Prospective Studies

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