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DOUBLE-BLIND TRIAL OF A PROGESTIN IN HABITUAL ABORTION

J W GOLDZIEHER

  • Baylor College of Medicine ROR

JAMA, 188(7), 651-654

DOI 10.1001/jama.1964.03060330031008 PMID 14121287

Abstract

Study of 54 habitual aborters with low or normal pregnanediol excretion, in a double-blind trial, revealed the spontaneous-salvage rate and the possible benefit of therapy with medroxyprogesterone acetate. The salvage rate in the placebo group with the worst prognosis (never a term pregnancy, low pregnanediol in the current pregnancy) was ten of 13, and the salvage rate in the other placebo groups showed no statistically significant difference. In view of this high spontaneous salvage rate, the numbers required to demonstrate a therapeutic effect of progestin administration are prohibitively large. This indicates the need for new criteria to pinpoint cases with a poor prognosis, and it raises the question whether habitual abortion is a disease entity or a statistical coincidence.

Topics

Infertility > Recurrent Pregnancy Loss > Progesterone TherapyReproductive Endocrinology > Progesterone > Miscarriage PreventionResearch Methodology > Randomized Controlled Trials > Placebo-Controlled Studies
habitual abortion progestin double blind trial, medroxyprogesterone acetate recurrent miscarriage treatment, progesterone supplementation habitual aborters pregnanediol, spontaneous salvage rate recurrent pregnancy loss, Goldzieher habitual abortion progestin trial, low pregnanediol excretion miscarriage prognosis, placebo controlled trial recurrent spontaneous abortion, progesterone therapy miscarriage prevention efficacy, habitual abortion disease entity or statistical coincidence, recurrent pregnancy loss spontaneous resolution rate
PMID 14121287 14121287 DOI 10.1001/jama.1964.03060330031008 10.1001/jama.1964.03060330031008

Cite this article

Goldzieher, J. W. (1964). Double-blind trial of a progestin in habitual abortion. *JAMA*, *188*(7), 651-654. https://doi.org/10.1001/jama.1964.03060330031008

Keywords

Abortion, Habitual, Abortion, Induced, Abortion, Spontaneous, Biomedical Research, Double-Blind Method, Female, Humans, Medroxyprogesterone, Pregnancy, Pregnanediol, Progestins, Prognosis, Statistics As Topic, Urine, Progestins, Medroxyprogesterone, Pregnanediol, ABORTION, HABITUAL, CLINICAL RESEARCH, MEDROXYPROGESTERONE, PREGNANEDIOL, PROGNOSIS, STATISTICS, URINE

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