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Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat

Kilic-Okman T et al., 2003

Fertility and sterility, 80(6), 1330-1332

DOI 10.1016/j.fertnstert.2003.05.002 PMID 14667861 Source

Abstract

Objective

To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E2, FSH, LH, and T.

Design

Controlled prospective study.

Setting

University research laboratory. ANIMAL(S): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age. INTERVENTION(S): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 microg/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized. MAIN OUTCOME MEASURE(S): Number of mature follicles, endometrial thickness, and serum levels of hormones. RESULT(S): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ. CONCLUSION(S): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate.

Topics

Reproductive Endocrinology > Ovulation > InductionInfertility > Female Factor > Ovulatory DysfunctionDiagnostics > Hormone Assays > FSH
letrozole versus clomiphene ovulation induction, aromatase inhibitor ovarian stimulation, letrozole follicular development, clomiphene citrate endometrial effects, ovulation induction comparison rat model, letrozole fsh lh response, clomiphene endometrial thickness, aromatase inhibitor fertility treatment, letrozole versus clomid follicle count, ovarian stimulation animal model, letrozole hormonal effects ovulation, clomiphene citrate follicular maturation

Cite this article

Kilic-Okman, T., Kucuk, M., & Altaner, S. (2003). Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat. *Fertility and sterility*, *80*(6), 1330-1332. https://doi.org/10.1016/j.fertnstert.2003.05.002

Keywords

Animals, Cell Count, Clomiphene, Endometrium, Estradiol, Female, Fertility Agents, Follicle Stimulating Hormone, Letrozole, Luteinizing Hormone, Nitriles, Ovarian Follicle, Rats, Wistar, Reference Values, Testosterone, Triazoles

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