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Common genetic changes between endometriosis and ovarian cancer

Obata K et al., 2000

Gynecologic and obstetric investigation, 50 Suppl 1(Suppl. 1), 39-43

DOI 10.1159/000052877 PMID 11093060 Source

Abstract

We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. Frequent LOH was observed on chromosome 6q (60.0%) and chromosome 10q (40.0%) in ovarian atypical endometriosis, but no PTEN mutations were observed. These findings support the hypothesis that endometrioid and clear cell ovarian carcinomas may arise through malignant transformation of endometriotic lesions.

Topics

Endometriosis > Pathophysiology > GeneticsEndometriosis > Pathophysiology > Mechanisms
endometriosis ovarian cancer risk, pten mutations endometriosis, malignant transformation endometriotic lesions, endometrioid ovarian cancer pathogenesis, genetic changes endometriosis, loss of heterozygosity endometriosis, atypical endometriosis cancer risk, clear cell carcinoma endometriosis, endometriosis long-term outcomes, molecular genetics endometriosis

Cite this article

Obata, K., & Hoshiai, H. (2000). Common genetic changes between endometriosis and ovarian cancer. *Gynecologic and obstetric investigation*, *50 Suppl 1*(Suppl. 1), 39-43. https://doi.org/10.1159/000052877

Keywords

Adenocarcinoma, Clear Cell, Carcinoma, Endometrioid, DNA Mutational Analysis, Endometriosis, Female, Genes, Tumor Suppressor, Humans, Loss of Heterozygosity, Mutation, Ovarian Neoplasms, PTEN Phosphohydrolase, Phosphoric Monoester Hydrolases, Sensitivity and Specificity, Tumor Suppressor Proteins, PTEN Protein, Human

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