Clonidine in the treatment of premenstrual syndrome: a subgroup study
The Journal of clinical psychiatry, 49(2), 62-63, 1988
Abstract
The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels. All of the women received clonidine and placebo in a double-blind cross-over design that spanned four menstrual cycles. Clonidine was significantly (p less than .05) more effective than placebo in reducing symptoms.
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Cite this article
Giannini, A. J., Sullivan, B., Sarachene, J., & Loiselle, R. H. (1988). Clonidine in the treatment of premenstrual syndrome: a subgroup study. *The Journal of clinical psychiatry*, *49*(2), 62-63.
Giannini AJ, Sullivan B, Sarachene J, Loiselle RH. Clonidine in the treatment of premenstrual syndrome: a subgroup study. J Clin Psychiatry. 1988;49(2):62-63.
Giannini, Andrea J., et al. "Clonidine in the treatment of premenstrual syndrome: a subgroup study." *The Journal of clinical psychiatry*, vol. 49, no. 2, 1988, pp. 62-63.
Keywords
Adult, Clinical Trials As Topic, Clonidine, Double-Blind Method, Female, Humans, Placebos, Premenstrual Syndrome, Psychiatric Status Rating Scales, beta-Endorphin