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Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects

R Andersen, P Roy-Byrne, D R Rubinow, M.Christine Hoban, D.Scott Galloway, Peter Roy‐Byrne, G N Grover, G R Merriam

  • National Institute of Mental Health ROR
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development ROR
  • National Institutes of Health ROR

American Journal of Obstetrics and Gynecology, 158(1), 5-11

DOI 10.1016/0002-9378(88)90765-x PMID 2962499

Abstract

A variety of hypotheses have been proposed to explain the premenstrual syndromes. These hypotheses serve as rationales for an equally diverse range of proposed treatments. To investigate these hypotheses, we obtained multiple blood samples across the menstrual cycle in women with well-characterized menstrually related mood disorder and in control subjects. No diagnosis-related differences were observed in the levels or patterns of secretion of progesterone, estradiol, follicle-stimulating hormone, luteinizing hormone, testosterone-estradiol-binding globulin, dehydroepiandrosterone sulfate, dihydrotestosterone, prolactin, or cortisol. Our data suggest that premenstrual syndrome does not represent a simple hormonal deficiency and that the cited rationales for several of the proposed treatments are of questionable merit.

Topics

Menstrual Cycle > Premenstrual Disorders > Hormonal EtiologyReproductive Endocrinology > Hormone Profiles > Menstrual CycleResearch Methodology > Study Design > Case-Control Studies
premenstrual syndrome hormone levels no difference controls, menstrually related mood disorder plasma hormone changes, progesterone estradiol premenstrual syndrome etiology, Rubinow PMS hormonal deficiency hypothesis refuted, menstrual cycle hormone profiles mood disorder controls, premenstrual syndrome not simple hormonal deficiency, FSH LH testosterone prolactin cortisol menstrual cycle mood, DHEAS dihydrotestosterone premenstrual syndrome, premenstrual mood disorder hormone secretion patterns, menstrual cycle serial blood sampling hormone levels PMS
PMID 2962499 2962499 DOI 10.1016/0002-9378(88)90765-x 10.1016/0002-9378(88)90765-x

Cite this article

Rubinow, D. R., Hoban, M. C., Grover, G. N., Galloway, D. S., Roy-Byrne, P., Andersen, R., & Merriam, G. R. (1988). Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects. *American journal of obstetrics and gynecology*, *158*(1), 5-11. https://doi.org/10.1016/0002-9378(88)90765-x

Keywords

Dehydroepiandrosterone/analogs & Derivatives/blood, Dehydroepiandrosterone Sulfate, Dihydrotestosterone/blood, Estradiol/blood, Female, Follicle Stimulating Hormone/blood, Hormones/blood, Humans, Hydrocortisone/blood, Luteinizing Hormone/blood, Menstrual Cycle, Mood Disorders/blood, Premenstrual Syndrome/blood, Prolactin/blood, Sex Hormone-Binding Globulin/analysis, Testosterone/blood, Hormones, Sex Hormone-Binding Globulin, Dihydrotestosterone, Testosterone, Dehydroepiandrosterone, Estradiol, Dehydroepiandrosterone Sulfate, Prolactin, Luteinizing Hormone, Follicle Stimulating Hormone, Hydrocortisone

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