The opiate-like peptide beta-endorphin and adrenocorticotropin are concomitantly secreted in increased amounts by the adenohypophysis in response to acute stress or long-term adrenalectomy as well as in vitro in response to purified corticotropin releasing factor and other secretagogues. Conversely, administration of the synthetic glucocorticoid dexamethasone inhibits the secretion of both adrenocorticotropin and beta-endorphin. Thus, both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin.
PMID 197601 197601 DOI 10.1126/science.197601 10.1126/science.197601
Cite this article
Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977). beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. *Science (New York, N.Y.)*, *197*(4311), 1367-1369. https://doi.org/10.1126/science.197601
Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, et al. beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science. 1977;197(4311):1367-1369. doi:10.1126/science.197601
Guillemin, R., et al. "beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland." *Science (New York, N.Y.)*, vol. 197, no. 4311, 1977, pp. 1367-1369.
Keywords
Adrenocorticotropic Hormone/blood/metabolism, Amino Acid Sequence, Animals, Corticotropin-Releasing Hormone/pharmacology, Endorphins/blood/metabolism, Hypophysectomy, Male, Peptides/metabolism, Pituitary Gland/metabolism, Protein Precursors/metabolism, Rats, Stress, Physiological/blood, Time Factors, Endorphins, Peptides, Protein Precursors, Adrenocorticotropic Hormone, Corticotropin-Releasing Hormone
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