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Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial

Alan H DeCherney, Noya Galai, Emily M Mitchell, Sunni L Mumford, Torie Comeaux Plowden, Rose G Radin, Enrique F Schisterman, Karen C Schliep, Robert M Silver, Lindsey A Sjaarda, Joseph B Stanford, Shvetha M Zarek

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development ROR
  • University of Haifa ROR
  • National Institutes of Health ROR
  • University of Utah ROR
  • Intermountain Healthcare ROR

Fertility and sterility, 105(4), 946-952.e2

DOI 10.1016/j.fertnstert.2015.12.003 PMID 26707905

Abstract

Objective

To evaluate if antimüllerian hormone (AMH) is associated with pregnancy loss.

Design

Prospective cohort study within a block-randomized, double-blind, placebo-controlled trial of low-dose aspirin.

Setting

Not applicable. PATIENT(S): Women (n = 1,228) were of ages 18-40 years with a history of one to two pregnancy losses and were actively attempting pregnancy without fertility treatment. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): Pregnancy loss. RESULT(S): Relative risks (and 95% confidence interval [CIs]) of human chorionic gonadotropin (hCG)-detected and clinical pregnancy loss were assessed with the use of log binomial models with robust variance and inverse probability weights adjusted for age, race, body mass index, income, trial treatment assignment, parity, number of previous losses, and time since most recent loss. AMH levels were defined as: low (<1.00 ng/mL; n = 124), normal (referent; 1.00-3.5 ng/mL; n = 595), and high (>3.5 ng/mL; n = 483). Of the 1,202 women with baseline AMH data, 19 (17.3%) with low AMH experienced a clinical loss, compared with 61 (11.4%) with normal AMH and 50 (11.8%) with high AMH levels. Low or high AMH levels, compared with normal AMH, were not associated with clinical loss. Results for hCG-detected pregnancy loss mirrored those of clinical loss. CONCLUSION(S): AMH values were not associated with hCG-detected or clinical pregnancy loss in unassisted conceptions in women with a history of one to two previous losses. Our data do not support routine AMH testing for prediction of pregnancy loss. Clinical

Trial Registration Number

NCT00467363.

Topics

InfertilityReproductive Endocrinology
anti-Mullerian hormone pregnancy loss, AMH fecundability prospective study, ovarian reserve pregnancy loss risk, AMH aspirin trial EAGeR, low AMH miscarriage association, serum AMH reproductive outcomes, ovarian reserve marker fertility, AMH pregnancy loss prediction, antimullerian hormone subfertility, AMH live birth rate association
PMID 26707905 26707905 DOI 10.1016/j.fertnstert.2015.12.003 10.1016/j.fertnstert.2015.12.003

Cite this article

Zarek, S. M., Mitchell, E. M., Sjaarda, L. A., Mumford, S. L., Silver, R. M., Stanford, J. B., Galai, N., Schliep, K. C., Radin, R. G., Plowden, T. C., DeCherney, A. H., & Schisterman, E. F. (2016). Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial. *Fertility and sterility*, *105*(4), 946-952.e2. https://doi.org/10.1016/j.fertnstert.2015.12.003

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