Abstract
Objective To evaluate the effects of the expanded polytetrafluoroethylene barrier (PTFE), Gore-Tex Surgical Membrane, in reducing postmyomectomy adhesion formation.
Design Multicenter randomized clinical trial.
Interventions Twenty-seven women having myomectomy with at least two incisions on the uterine fundus and posterior uterine wall of similar length were enrolled in the study. At laparotomy, the two incision sites were randomly assigned to be covered with PTFE or were left uncovered. A second-look laparoscopy to evaluate adhesion formation and to lyse adhesions was done from 2 to 6 weeks after the myomectomy. Adhesions were scored using a 0- to 11-point scoring system.
Results At laparoscopy, 15 of 27 incisions covered with PTFE (55.6%) and only 2 of 27 uncovered sites (7.4%) were completely free of adhesions. The mean adhesion score at the PTFE sites was significantly lower (1.88 +/- 0.46; SEM) than at the control sites (7.55 +/- 0.57).
Conclusion The PTFE barrier is effective in reducing postmyomectomy adhesion formation.
Gore-Tex PTFE barrier postmyomectomy adhesion prevention, expanded polytetrafluoroethylene adhesion reduction myomectomy, myomectomy adhesion formation randomized clinical trial, adhesion barrier uterine surgery fertility preservation, Gore-Tex surgical membrane reproductive surgery outcomes, postoperative adhesion prevention uterine incision, Myomectomy Adhesion Multicenter Study Group PTFE, second look laparoscopy adhesion scoring myomectomy, adhesion prevention methods gynecologic surgery comparison, uterine fundus posterior wall adhesion barrier
Keywords
Adolescent, Adult, Female, Humans, Laparoscopy, Leiomyoma/surgery, Polytetrafluoroethylene, Postoperative Complications/prevention & Control, Reoperation, Tissue Adhesions/prevention & Control, Uterine Diseases/prevention & Control, Uterine Neoplasms/surgery, Polytetrafluoroethylene