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Amniotic fluid concentrations of adrenomedullin in preterm labor

Marinoni E et al., 1999

Obstetrics and gynecology, 93(6), 964-967

DOI 10.1016/s0029-7844(98)00551-1 PMID 10362163 Source

Abstract

Objective

To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor.

Methods

We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocentesis from 36 women with clinical diagnosis of preterm labor or preterm premature rupture of membranes (PROM) and from 18 normal pregnant women.

Results

Amniotic fluid from cases of PROM and failure to respond to tocolysis were associated significantly with higher amniotic fluid adrenomedullin concentrations (177.0 +/- 22.5 pg/mL and 182.7 +/- 22.0 pg/mL, respectively, P < .01) than that from uncomplicated pregnancies (101.2 +/- 28.1 pg/mL) or preterm labor responsive to tocolysis (102.3 +/- 26.8 pg/mL).

Conclusion

Amniotic fluid adrenomedullin is higher than normal in cases of PROM and preterm labor unresponsive to tocolysis, perhaps indicating enhanced synthesis from placenta or fetal membranes being stimulated by bacterial products.

Topics

Pregnancy > Preterm Birth > Risk FactorsDiagnostics > Biomarker Monitoring > Urinary Metabolites
adrenomedullin preterm labor, amniotic fluid biomarkers prematurity, preterm PROM biomarkers, tocolysis failure prediction, preterm premature rupture membranes markers, amniotic fluid peptides preterm birth, bacterial products preterm labor, placental biomarkers preterm delivery, adrenomedullin pregnancy complications

Cite this article

Marinoni, E., Di Iorio, R., Letizia, C., Villaccio, B., Alberini, A., & Cosmi, E. V. (1999). Amniotic fluid concentrations of adrenomedullin in preterm labor. *Obstetrics and gynecology*, *93*(6), 964-967. https://doi.org/10.1016/s0029-7844(98)00551-1

Keywords

Adrenomedullin, Adult, Amniotic Fluid, Female, Fetal Membranes, Premature Rupture, Humans, Obstetric Labor, Premature, Peptides, Pregnancy

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