American Journal of Obstetrics and Gynecology, 155(3), 667-670
With the use of a rabbit surgical model, the ability of 1%, 2%, and 3% solutions of sodium carboxymethylcellulose to reduce postoperative uterine adhesions was determined. At all concentrations sodium carboxymethylcellulose was more effective than either 32% dextran 70 or heparinized lactated Ringer's solution. Neither the dextran nor Ringer's solution had a significant (p less than or equal to 0.05) effect. The beneficial effects of sodium carboxymethylcellulose were closely dose-dependent (correlation coefficient 0.97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety.
Fredericks, C. M., Kotry, I., Holtz, G., Askalani, A. H., & Serour, G. I. (1986). Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions. *American journal of obstetrics and gynecology*, *155*(3), 667-670. https://doi.org/10.1016/0002-9378(86)90304-2
Fredericks CM, Kotry I, Holtz G, Askalani AH, Serour GI. Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions. Am J Obstet Gynecol. 1986;155(3):667-670. doi:10.1016/0002-9378(86)90304-2
Fredericks, C. M., et al. "Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions." *American journal of obstetrics and gynecology*, vol. 155, no. 3, 1986, pp. 667-670.
Animals, Autopsy, Carboxymethylcellulose Sodium/administration & Dosage/therapeutic Use, Dextrans/administration & Dosage, Dose-Response Relationship, Drug, Female, Isotonic Solutions/administration & Dosage, Methylcellulose/analogs & Derivatives, Microsurgery/methods, Peritoneal Diseases/prevention & Control, Postoperative Complications/prevention & Control, Rabbits, Ringer's Lactate, Solutions, Tissue Adhesions/prevention & Control, Uterus/surgery, Dextrans, Isotonic Solutions, Ringer's Lactate, Solutions, Methylcellulose, Carboxymethylcellulose Sodium