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A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles

Propst AM et al., 2001

Fertility and sterility, 76(6), 1144-1149

DOI 10.1016/s0015-0282(01)02872-2 PMID 11730742 Source

Abstract

Objective

To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET.

Design

Randomized, open-label study.

Setting

Academic medical center. PATIENT(S): Two hundred and one women undergoing IVF-ET. INTERVENTION(S): Women were randomized to supplementation with Crinone 8% (90 mg once daily) or IM progesterone (50 mg once daily) beginning the day after oocyte retrieval. MAIN OUTCOME MEASURE(S): Pregnancy, embryo implantation, and live birth rates. RESULT(S): The women randomized to luteal phase supplementation with IM progesterone had significantly higher clinical pregnancy (48.5% vs. 30.4%; odds ratio [OR], 2.16; 95% confidence interval [CI], 1.21, 3.87), embryo implantation (24.1% vs. 17.5%; OR, 1.89; 95% CI, 1.08, 3.30), and live birth rates (39.4% vs. 24.5%; OR, 2.00; 95% CI, 1.10, 3.70) than women randomized to Crinone 8%. CONCLUSION(S): In women undergoing IVF-ET, once-a-day progesterone supplementation with Crinone 8%, beginning the day after oocyte retrieval, resulted in significantly lower embryo implantation, clinical pregnancy, and live birth rates compared with women supplemented with IM progesterone.

Topics

Reproductive Endocrinology > Progesterone > SupplementationReproductive Endocrinology > Luteal Phase > Support
progesterone support IVF comparison, crinone versus intramuscular progesterone, vaginal progesterone gel ivf outcomes, luteal phase support IVF, intramuscular progesterone pregnancy rates, progesterone supplementation embryo transfer, crinone 8% effectiveness, progesterone delivery route comparison

Cite this article

Propst, A. M., Hill, J. A., Ginsburg, E. S., Hurwitz, S., Politch, J., & Yanushpolsky, E. H. (2001). A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. *Fertility and sterility*, *76*(6), 1144-1149. https://doi.org/10.1016/s0015-0282(01)02872-2

Keywords

Administration, Intravaginal, Adult, Age Factors, Embryo Transfer, Estradiol, Female, Fertilization in Vitro, Gels, Humans, Injections, Intramuscular, Male, Ovulation Induction, Pregnancy, Progesterone, Statistics, Nonparametric, Crinone

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