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A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction

Boostanfar R et al., 2001

Fertility and sterility, 75(5), 1024-1026

DOI 10.1016/s0015-0282(01)01749-6 PMID 11334921 Source

Abstract

Objective

To compare the rates of ovulation and pregnancy after tamoxifen citrate (TMX) or clomiphene citrate (CC) among anovulatory women with infertility.

Design

Prospective randomized trial.

Setting

Infertility clinic in a university teaching hospital. PATIENT(S): Eighty-six anovulatory women under 40 years of age undergoing ovulation induction. INTERVENTION(S): The women were assigned randomly to receive either TMX or CC on cycle days 5-9. MAIN OUTCOME MEASURE(S): Rates of ovulation and pregnancy for the two treatment modalities. RESULTS(S): The overall rate of ovulation in the TMX group was 50 of 113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in the TMX group and 6 pregnancies in the CC group. The cycle fecundity per ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group. CONCLUSION(S): The overall rate of ovulation and pregnancy were similar with TMX and CC. TMX is a suitable alternative agent to CC in the management of anovulatory infertility.

Topics

Infertility > Female Factor > Ovulatory DysfunctionReproductive Endocrinology > Ovulation > InductionContraception/Comparison > Effectiveness > Typical Use
clomiphene citrate ovulation induction, tamoxifen ovulation induction, anovulatory infertility treatment, clomiphene vs tamoxifen, ovulation induction medications comparison, selective estrogen receptor modulator fertility, anovulation pharmacological treatment, ovulation rate pregnancy rate comparison, alternative to clomiphene

Cite this article

Boostanfar, R., Jain, J. K., Mishell DR Jr, & Paulson, R. J. (2001). A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction. *Fertility and sterility*, *75*(5), 1024-1026. https://doi.org/10.1016/s0015-0282(01)01749-6

Keywords

Adult, Clomiphene, Female, Humans, Infertility, Luteinizing Hormone, Male, Ovulation Induction, Pregnancy, Pregnancy Rate, Prospective Studies, Selective Estrogen Receptor Modulators, Tamoxifen

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