A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles
Gian Carlo Di Renzo, S Gerli, C Manna, V Unfer, L Costabile, D Rossetti
To compare the effectiveness of i.m. P and 17alpha-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles.
Design
Prospective, randomized study.
Setting
Patients undergoing IVF-ET in our Centers.
PATIENT(S): The inclusion criteria were the use of GnRH down-regulation and aged <40 years.
INTERVENTION(S): A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily).
MAIN OUTCOME MEASURE(S): The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy.
RESULT(S): No difference was found in the main outcome parameters considered.
CONCLUSION(S): Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.
intramuscular progesterone luteal phase support IVF, 17-alpha-hydroxyprogesterone caproate IVF-ET luteal support, progesterone versus 17-HPC randomized IVF study, luteal phase supplementation in vitro fertilization outcomes, progesterone in oil versus 17-HPC pregnancy rates, prospective randomized study luteal phase support protocols, GnRH down-regulation IVF progesterone supplementation, clinical pregnancy rate luteal support IVF-ET cycles, injectable progesterone comparison assisted reproduction, Unfer V progesterone IVF luteal phase
PMID 11476795 11476795 DOI 10.1016/s0015-0282(01)01901-x 10.1016/s0015-0282(01)01901-x
Cite this article
Costabile, L., Gerli, S., Manna, C., Rossetti, D., Di Renzo, G. C., & Unfer, V. (2001). A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. *Fertility and sterility*, *76*(2), 394-396. https://doi.org/10.1016/s0015-0282(01)01901-x
Costabile L, Gerli S, Manna C, Rossetti D, Di Renzo GC, Unfer V. A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. Fertil Steril. 2001;76(2):394-396. doi:10.1016/s0015-0282(01)01901-x
Costabile, L., et al. "A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles." *Fertility and sterility*, vol. 76, no. 2, 2001, pp. 394-396.
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