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A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles

Costabile L et al., 2001

Fertility and sterility, 76(2), 394-396

DOI 10.1016/s0015-0282(01)01901-x PMID 11476795 Source

Abstract

Objective

To compare the effectiveness of i.m. P and 17alpha-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles.

Design

Prospective, randomized study.

Setting

Patients undergoing IVF-ET in our Centers. PATIENT(S): The inclusion criteria were the use of GnRH down-regulation and aged <40 years. INTERVENTION(S): A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily). MAIN OUTCOME MEASURE(S): The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy. RESULT(S): No difference was found in the main outcome parameters considered. CONCLUSION(S): Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.

Topics

Reproductive Endocrinology > Luteal Phase > SupportReproductive Endocrinology > Progesterone > SupplementationInfertility > Female Factor > Ovulatory Dysfunction
progesterone vs 17-hydroxyprogesterone caproate ivf, luteal phase support progesterone formulations, 17-hpc ivf embryo transfer outcomes, intramuscular progesterone luteal support, progesterone in oil vs 17-ohp ivf, luteal phase 17-hydroxyprogesterone pregnancy rate, ivf luteal support progesterone comparison, 17-hpc dosing luteal phase, progesterone formulation ivf clinical pregnancy, randomized trial luteal progesterone ivf

Cite this article

Costabile, L., Gerli, S., Manna, C., Rossetti, D., Di Renzo, G. C., & Unfer, V. (2001). A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. *Fertility and sterility*, *76*(2), 394-396. https://doi.org/10.1016/s0015-0282(01)01901-x

Keywords

17 alpha-Hydroxyprogesterone Caproate, Adult, Embryo Transfer, Female, Fertilization in Vitro, Humans, Hydroxyprogesterones, Infertility, Injections, Intramuscular, Male, Outcome Assessment, Health Care, Pregnancy, Progesterone, Prospective Studies

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