0

A prospective controlled study of luteal and endometrial abnormalities in an infertile population

Batista MC et al., 1996

Fertility and sterility, 65(3), 495-502

PMID 8774276 Source

Abstract

Objective

To investigate whether luteal and endometrial abnormalities occur more frequently in an infertile population and thus contribute to infertility.

Design

Prospective controlled clinical study.

Setting

Outpatient clinic in an academic research institution.

Participants

Thirty-three fertile controls and 31 infertile women without ovulatory disorders, tubal disease, or male factors.

Interventions

All women underwent an endometrial biopsy 9 days after the LH surge followed by an IM injection of 5,000 IU hCG. Blood samples were drawn immediately before hCG administration for serum P and placental protein 14 (PP14) measurements, at 6 hours after hCG stimulation for serum P concentrations, and on day 5 after hCG administration for serum PP14 levels.

Main outcome measures

Histologic dating of the endometrium and serum P and PP14 measurements.

Results

Abnormal endometrial biopsies occurred more frequently in infertile (43%) than in fertile women (9%). Except for one case, these specimens were not associated with low hCG-stimulated P levels. Serum PP14 measurements varied widely and did not discriminate subjects with abnormal endometrial development.

Conclusions

Disruption of endometrial maturation without a concomitant defect of the corpus luteum occurs more frequently in an infertile population and thus may contribute to infertility.

Topics

Infertility > Unexplained > WorkupReproductive Endocrinology > Luteal Phase > DeficiencyDiagnostics > Hormone Assays > ProgesteroneDiagnostics > Biomarker Monitoring > Urinary Metabolites
luteal phase defect infertility, endometrial biopsy abnormal infertile women, corpus luteum dysfunction unexplained infertility, placental protein 14 endometrial maturation, endometrial development without luteal defect, hCG stimulated progesterone testing, timed endometrial biopsy fertility evaluation, endometrial factor infertility diagnosis, luteal phase support endometrial abnormalities, progesterone levels normal but endometrium abnormal, endometrial maturation disruption infertility, luteal phase progesterone PP14 measurement

Cite this article

Batista, M. C., Cartledge, T. P., Zellmer, A. W., Merino, M. J., Nieman, L. K., Loriaux, D. L., & Merriam, G. R. (1996). A prospective controlled study of luteal and endometrial abnormalities in an infertile population. *Fertility and sterility*, *65*(3), 495-502.

Keywords

Adult, Biopsy, Chorionic Gonadotropin, Corpus Luteum, Endometrium, Female, Glycodelin, Glycoproteins, Humans, Infertility, Menstrual Cycle, Middle Aged, Pregnancy Proteins, Progesterone, Prospective Studies, Time Factors, PAEP Protein, Human

Related articles