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A cytogenetic study of 1000 spontaneous abortions

Hassold T et al., 1980

Annals of human genetics, 44(2), 151-178

DOI 10.1111/j.1469-1809.1980.tb00955.x PMID 7316468 Source

Abstract

Cytogenetic analysis of 1000 spontaneous abortions showed 463 to have an abnormal chromosome constitution. The proportion of chromosome abnormalities varied with the gestational age of the abortus and the type of tissue cultured but was not significantly different among the five racial groups represented in the study population. It was suggested that differences in the rate of chromosome abnormalities among cytogenetic studies of spontaneous abortions were the result of methodological differences in sample selection rather than real biological variation among study populations. The only factor found to be unequivocally associated with the aetiology of chromosome abnormalities in spontaneous abortions was increasing maternal age in trisomies.

Topics

Pregnancy > Recurrent Loss > EtiologyPregnancy > Outcomes > Miscarriage Rates
chromosome abnormalities miscarriage, spontaneous abortion cytogenetics, trisomy miscarriage maternal age, pregnancy loss karyotype analysis, chromosomal causes early pregnancy loss, miscarriage genetic testing results, recurrent miscarriage chromosome studies, maternal age and pregnancy loss, cytogenetic analysis spontaneous abortion, gestational age chromosome abnormalities, aneuploidy miscarriage rates

Cite this article

Hassold, T., Chen, N., Funkhouser, J., Jooss, T., Manuel, B., Matsuura, J., Matsuyama, A., Wilson, C., Yamane, J. A., & Jacobs, P. A. (1980). A cytogenetic study of 1000 spontaneous abortions. *Annals of human genetics*, *44*(2), 151-178. https://doi.org/10.1111/j.1469-1809.1980.tb00955.x

Keywords

Abortion, Spontaneous, Cells, Cultured, Chromosome Aberrations, Ethnicity, Female, Gestational Age, Humans, Karyotyping, Male, Maternal Age, Paternal Age, Pregnancy, Sex Chromosome Aberrations, Sex Ratio, Trisomy

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