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A comparative study of human chorionic gonadotropin, placebo, and bed rest for women with early threatened abortion

Harrison RF, 1993

International journal of fertility and menopausal studies, 38(3), 160-165

PMID 8348164 Source

Abstract

Objective

To compare the effect of hCG therapy with placebo or bed rest in women with threatened abortion.

Design

Random assignment, double-blind.

Setting

Community hospitals. PATIENTS AND

Interventions

Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed.

Main outcome measures

Abortion vs. continuation of pregnancy at 16 weeks' gestation.

Results

Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1.

Conclusions

hCG is significantly better than bed rest.

Topics

Pregnancy > Recurrent Loss > TreatmentReproductive Endocrinology > Progesterone > SupplementationRRM Methods > NaProTECHNOLGY > Clinical OutcomesPregnancy > Outcomes > Miscarriage Rates
hcg for threatened miscarriage, early pregnancy bleeding treatment, threatened abortion progesterone levels, human chorionic gonadotropin threatened abortion, first trimester bleeding hcg therapy, progesterone monitoring early pregnancy, bed rest vs hcg miscarriage, early pregnancy support hormonal, hcg injection threatened abortion, naprotechnology early pregnancy protocol, progesterone luteal support threatened loss, hormonal support recurrent miscarriage

Cite this article

Harrison, R. F. (1993). A comparative study of human chorionic gonadotropin, placebo, and bed rest for women with early threatened abortion. *International journal of fertility and menopausal studies*, *38*(3), 160-165.

Keywords

Abortion, Threatened, Adult, Bed Rest, Birth Weight, Chi-Square Distribution, Chorionic Gonadotropin, Double-Blind Method, Female, Humans, Male, Pregnancy, Pregnancy Trimester, First, Progesterone, Sex Ratio, Treatment Outcome

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